P 191 Corneal endothelial toxicity of liposome encapsulated 5-fluorouridine in rabbits
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P 191 Corneal endothelial toxicity of liposome encapsulated 5-fluorouridine in rabbits
P"rpse: To investigate the clinical and histological toxicity of the exposure of the :rabbit cornea1 endothelium to anterior chamber injection of liposome-encapsulated 5-fluorouridine (LS-FUR) at concentrations of 1 mg/ml and 0.38 mg/ml and intravitreal injection of I.5FUR at 1 mg/ml. M*thOdS : A total of 12 New Zealand white rabbits were divided in three groups: A) Anterror chamber rnjectian o...
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Eurppse : To evaluate the presence of Neuron Specific Enolase (NSE) in subretinal fluid (SRF? as a uotential marker for retinal damaee and to correlate these b&Vets ‘tith r&al detachment (RD) pzmmwem kS.E is a reliablemarkerofneuronallysisintbecerebro-~fluidinbraindamage. Levels of NSE in the aqueous humour are also elevated in retiwblastoma NSEhaskdetectedinalllayenofnmmal humanretinaexcepth4u...
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Pm-mme. The function of RPE is well known in PVR. Pharmacologic agents have been extensively shldied both experimentally and clinically. Few reports have derailled the interactions of a”timitctic drugs on the microtubule network. The aim of this study is to visualize by indirect immunofluwescence the modification of the microtubule network of cultured pig RPE cells by colchicina and taxol. Yetb...
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Background and Objectives: The most common problems limiting the medical use of aminoglycosides have been the nephro- and oto-toxicities as well as the increasing bacterial resistance. Encapsulation of drugs into liposomes enhances their efficacy while reducing their toxicities. The aim of this study was to evaluate the antimicrobial activity of free and liposomal amikacin. Material and Metho...
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ژورنال
عنوان ژورنال: Vision Research
سال: 1995
ISSN: 0042-6989
DOI: 10.1016/0042-6989(95)90507-3